Volume 3, Issue 2-1, March 2015, Page: 18-21
Evaluation of Antimicrobial Activity of Curcumin Against Two Oral Bacteria
Najah A. Mohammed, Medical technology institute, Medical technical university (MTU), Baghdad, Iraq
Neama Y. Habil, Medical technology institute, Medical technical university (MTU), Baghdad, Iraq
Received: Dec. 21, 2014;       Accepted: Dec. 25, 2014;       Published: Jan. 27, 2015
DOI: 10.11648/j.acis.s.2015030201.14      View  3336      Downloads  327
Abstract
Oral pathogenic gram-positive bacteria, Streptococcus pyogenes (Strept.pyogenes) are caused severe human diseases with complications, including rheumatic fever, sepsis, severe soft-tissue invasion, and toxic-shock-like syndrome (TSLS). Whereas, Streptococcus mutants(Strept. mutans),described a key causative agent of caries and infective endocarditis. Therefore, the aim of this study was to evaluate the inhibitory effect of Curcumin on Strept. mutans and Strept.pyogenes growth in comparison with the antibiotic Ciprofloxacin using well diffusion method. Minimum Inhibitory Concentration (MICs) showed that curcumin-mediated growth inhibition of Strept. mutans and, Strept. pyogenes. Results showed that curcumin significantly inhibitedthe activity of Strept. mutans and Strept. pyogenes growth with inhibition zones, 9.7mm and 10.2 mm, respectively while the inhibition zone of Ciprofloxacin 15.52mm to 13.4mm against Strept. mutans, Strept. pyogenes respectively.The antimicrobial activity of curcumin on Strept. mutans and Strept. pyogenes growth suggests that the curcumin may be useful for controlling dental biofilms, subsequently dental caries formation.This study provides significant insights into the therapeutic effect of curcumin against pathogenic gram positive bacteria, suggesting its potential as an alternative therapy, and opens the way for further studies on identification of novel antimicrobial targets of curcumin.
Keywords
Curcumin, Antibacterial Activity, Minimum Inhibitory Concentration (MIC)
To cite this article
Najah A. Mohammed, Neama Y. Habil, Evaluation of Antimicrobial Activity of Curcumin Against Two Oral Bacteria, Automation, Control and Intelligent Systems. Special Issue:Artificial Nano Sensory System. Vol. 3, No. 2-1, 2015, pp. 18-21. doi: 10.11648/j.acis.s.2015030201.14
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